But even this change in FAF is far from 
as dramatic as the change of the melanoma. Nevi 
that show orange pigment (which is gathering of 
lipofuscin), subretinal fluid or growth should be 
suspected as being melanomas. Shields et al (2008) 
presented that orange pigment accumulations, 
subretinal fluid and RPE detachment are shown as 
hyperfluorescent. The hyperfluorescence from the 
orange pigment on the melanoma with the Canon